Axillary Reverse Mapping (ARM) Trial

New surgical technique for breast cancer could minimize side effects

If you’ve been diagnosed with breast cancer, you may be eligible to participate in a clinical trial underway at The University of Kansas Cancer Center. The axillary reverse mapping (ARM) trial investigates a new procedure to reduce side effects after lymph nodes are removed.

What is lymphedema?

One of the most common side effects associated with breast cancer treatment is lymphedema, or swelling of the arms due to faulty drainage of the lymph nodes. Depending on the extent of the surgery, between 20 percent and 50 percent of women undergoing surgery for breast cancer develop lymphedema, with side effects including arm numbness and difficulty moving the arm.

What does this clinical trial study?

This Phase 2 clinical trial investigates a new surgical technique for mapping and preserving the arm lymphatics in patients who have breast cancer and are undergoing a sentinel lymph node biopsy or an axillary lymph node dissection. These biopsy procedures are performed to see if the breast cancer has spread to the lymph nodes.

Identifying the arm lymphatics can better protect them during surgery, potentially decreasing the occurrence of lymphedema. The new surgical technique being studied may ultimately prevent or minimize side effects so patients can get back to their normal routines more quickly after breast cancer treatment.

What are the benefits and drawbacks to participating?

By participating in a clinical trial, you have access to new treatments not offered elsewhere. You also have access to regular medical attention from a highly qualified care team. You’ll contribute to cancer research, which can help other cancer patients in the future.

However, new treatments aren’t always better than the standard treatments. Study participants may be required to visit a doctor more often. Some health insurance plans may not cover all care costs involved, though some state and federal programs help patients pay for costs associated with clinical trials.

Am I eligible to participate?

You can participate in this clinical trial if you require lymph node evaluation for breast cancer, or if you are having a sentinel lymph node biopsy in association with a prophylactic mastectomy. You must meet specific criteria and go through a screening.

The study will include 211 participants who will continue to be evaluated for lymphedema for four years.

Where is treatment provided?

The surgical biopsy is performed at The University of Kansas Hospital in Kansas City, Kansas. Follow-up care is provided at The University of Kansas Cancer Center’s Richard and Annette Bloch Cancer Care Pavilion located near the hospital.

How can I learn more?

Call us at 913.588.1227 or toll free 800.332.6048.