KU Cancer Center highlights from AACR Annual Meeting

The AACR’s annual meeting program covers the latest discoveries across the spectrum of cancer research and highlights advancements in research and medicine from institutions all over the world. Like many conferences this year, the AACR meeting was held virtually. It was also divided into two sessions; the first meeting was held April 22-24 and the second meeting was held June 22-24.

The meeting featured a variety of sessions including a Clinical Plenary session, led by Weijing Sun, MD, director of Medical Oncology. Cancer center researchers shared findings from their work, which spans basic, translational and clinical research. Select presentations from the meeting are listed below. Abstracts are accessible to those with an AACR login.

Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting Notch signaling

Scott James Weir, Prasad Dandawate, Prabhu Ramamoorthy, Parthasarathy Ranjarajan, Robyn Wood, Amanda Brinker, Benjamin Woolbright, Mehmet Tanol, Tammy Ham, William McCulloch, Michael Dalton, Michael J. Baltezor, Roy A. Jensen, John A. Taylor III, Shrikant Anant.

Randomized clinical trial of a flaxseed lignan in pre-menopausal women at high risk for development of breast cancer

Carol J. Fabian, Seema A. Khan, Judy E. Garber, William C. Dooley, Lisa D. Yee, Carola M. Zalles, Trina Metheny, Teresa A. Phillips, Jinxiang Hu, Brian K. Petroff, Stephen D. Hursting, Bruce F. Kimler.

Dissecting the structural basis for rational inhibitor design: Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1

Lan Lan, Minli Xing, Maithri Kashipathy, Justin Douglas, Philip Gao, Kevin Battaile, Robert Hanzlik, Scott Lovell, Liang Xu.

Mitochondrial genetics appear to alter immune cell development/trafficking

Thomas C. Beadnell, Amanda E. Brinker, Cori Fain, Carolyn J. Vivian, Danny R. Welch.

Genomic analysis of infant KMT2A-r acute lymphoblastic leukemia reveals weak association with underlying germline cancer predisposition

Azhar Saeed, Midhat Farooqi, Byunggil Yoo, Rumen Kostadinov, Emily Farrow, Neil Miller, Patrick Brown, Erin Guest.