Jeffrey P. Krise, PhD

Dr. Jeff Krise is currently an associate professor of pharmaceutical chemistry at the University of Kansas. He holds a Bachelor of Science degree in pharmacy from Duquesne University (1993). He earned his PhD (with honors) from the Department of Pharmaceutical Chemistry at the University of Kansas in 1998. Dr. Krise completed one year of his PhD training at the Victorian College of Pharmacy (now Monash University) in Melbourne, Australia. Dr. Krise received postdoctoral training at Stanford University School of Medicine from 1998 to 2001 in the Department of Biochemistry. In 2001 he began his academic career at the University of North Carolina at Chapel Hill in the Division of Drug Delivery and Disposition. In 2004 he moved to back to the University of Kansas in the Department of Pharmaceutical Chemistry.

Amine-containing molecules and the induction of an expanded lysosomal volume phenotype: a structure-activity relationship study

Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: implications for an intracellular distribution-based drug interaction

Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications

Evaluating the roles of autophagy and lysosomal trafficking defects in intracellular distribution-based drug-drug interactions involving lysosomes

Intracellular Delivery and Disposition of Small-Molecular-Weight Drugs

Lysosomotropic properties of weakly basic anticancer agents promote cancer cell selectivity in vitro

NPC1 functions independently of NPC2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo

The Mechanisms and Therapeutics Consequences of Amine-Containing Drug Sequestration in Lysosomes

The role of lysosomes in limiting drug-induced toxicity in mice

Time-dependent effects of hydrophobic amine-containing drugs on lysosome structure and biogenesis in cultured human fibroblasts