2022 Research Highlights

Complete genomic and epigenetic maps of human centromeres. Science. 2022;376(6588):eabl4178. Epub 20220401. doi: 10.1126/science.abl4178. PubMed PMID: 35357911.

Altemose N, Logsdon GA, Bzikadze AV, Sidhwani P, Langley SA, Caldas GV, Hoyt SJ, Uralsky L, Ryabov FD, Shew CJ, Sauria MEG, Borchers M, Gershman A, Mikheenko A, Shepelev VA, Dvorkina T, Kunyavskaya O, Vollger MR, Rhie A, McCartney AM, Asri M, Lorig-Roach R, Shafin K, Lucas JK, Aganezov S, Olson D, de Lima LG, Potapova T, Hartley GA, Haukness M, Kerpedjiev P, Gusev F, Tigyi K, Brooks S, Young A, Nurk S, Koren S, Salama SR, Paten B, Rogaev EI, Streets A, Karpen GH, Dernburg AF, Sullivan BA, Straight AF, Wheeler TJ, Gerton JL, Eichler EE, Phillippy AM, Timp W, Dennis MY, O'Neill RJ, Zook JM, Schatz MC, Pevzner PA, Diekhans M, Langley CH, Alexandrov IA, Miga KH. 

Integrative analysis of drug response and clinical outcome in acute myeloid leukemia. Cancer Cell. 2022. Epub 20220720. doi: 10.1016/j.ccell.2022.07.002. PubMed PMID: 35868306.

Bottomly D, Long N, Schultz AR, Kurtz SE, Tognon CE, Johnson K, Abel M, Agarwal A, Avaylon S, Benton E, Blucher A, Borate U, Braun TP, Brown J, Bryant J, Burke R, Carlos A, Chang BH, Cho HJ, Christy S, Coblentz C, Cohen AM, d'Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Dibb J, Eide CA, English I, Hagler S, Harrelson H, Henson R, Ho H, Joshi SK, Junio B, Kaempf A, Kosaka Y, Laderas T, Lawhead M, Lee H, Leonard JT, Lin C, Lind EF, Liu SQ, Lo P, Loriaux MM, Luty S, Maxson JE, Macey T, Martinez J, Minnier J, Monteblanco A, Mori M, Morrow Q, Nelson D, Ramsdill J, Rofelty A, Rogers A, Romine KA, Ryabinin P, Saultz JN, Sampson DA, Savage SL, Schuff R, Searles R, Smith RL, Spurgeon SE, Sweeney T, Swords RT, Thapa A, Thiel-Klare K, Traer E, Wagner J, Wilmot B, Wolf J, Wu G, Yates A, Zhang H, Cogle CR, Collins RH, Deininger MW, Hourigan CS, Jordan CT, Lin TL, Martinez ME, Pallapati RR, Pollyea DA, Pomicter AD, Watts JM, Weir SJ, Druker BJ, McWeeney SK, Tyner JW. 

Listening to the patient voice adds value to cancer clinical trials. J Natl Cancer Inst. 2022. Epub 20220728. doi: 10.1093/jnci/djac128. PubMed PMID: 35900186.

Brundage MD, Crossnohere NL, O'Donnell J, Cruz Rivera S, Wilson R, Wu AW, David M, Kyte D, Reeve BB, Gilbert A, Chen RC, Calvert MJ, Snyder C. 

 An unexpected tumor suppressor role of SQSTM1/p62 in liver tumorigenesis. Autophagy. 2022;18(2):459-61. Epub 20211206. doi: 10.1080/15548627.2021.2008693. PubMed PMID: 34870542; PMCID: PMC8942560.

Chao X, Ni HM, Ding WX.

Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy. J Hepatol. 2022;76(3):639-51. Epub 20211025. doi: 10.1016/j.jhep.2021.10.014. PubMed PMID: 34710483; PMCID: PMC8858859.

Chao X, Wang S, Fulte S, Ma X, Ahamed F, Cui W, Liu Z, Rülicke T, Zatloukal K, Zong WX, Liu W, Ni HM, Ding WX. 

 

Effect of Varenicline Added to Counseling on Smoking Cessation Among African American Daily Smokers: The Kick It at Swope IV Randomized Clinical Trial. Jama. 2022;327(22):2201-9. doi: 10.1001/jama.2022.8274. PubMed PMID: 35699705.

Cox LS, Nollen NL, Mayo MS, Faseru B, Greiner A, Ellerbeck EF, Krebill R, Tyndale RF, Benowitz NL, Ahluwalia JS.

SOX9 acts downstream of YAP to decide liver cell fate and tumor types. J Hepatol. 2022;76(3):503-5. Epub 20211217. doi: 10.1016/j.jhep.2021.12.008. PubMed PMID: 34929213.

Ding WX, Sancho-Bru P. 

Clinical significance of FBXW7 loss of function in human cancers. Mol Cancer. 2022;21(1):87. Epub 20220326. doi: 10.1186/s12943-022-01548-2. PubMed PMID: 35346215; PMCID: PMC8962602.

Fan J, Bellon M, Ju M, Zhao L, Wei M, Fu L, Nicot C. 

Additional Benefits of Maintaining a Healthy Lifestyle After Quitting Smoking. JAMA Netw Open. 2022;5(9):e2232784. Epub 20220901. doi: 10.1001/jamanetworkopen.2022.32784. PubMed PMID: 36136337.

Faseru B, Fagan P, Okuyemi KS. 

Addressing Diversity, Equity, and Inclusion at the JNCI Journals. J Natl Cancer Inst. 2022;114(9):1207-8. doi: 10.1093/jnci/djac124. PubMed PMID: 36065087.

Ganz PA, Chen RC, Boehm AL. 

Evaluation of Telemedicine Use Among US Patients With Newly Diagnosed Cancer by Socioeconomic Status. JAMA Oncol. 2022;8(1):161-3. doi: 10.1001/jamaoncol.2021.5784. PubMed PMID: 34792526; PMCID: PMC8603229.

Katz AJ, Haynes K, Du S, Barron J, Kubik R, Chen RC.

Evaluation of the Durability of the Immune Humoral Response to COVID-19 Vaccines in Patients With Cancer Undergoing Treatment or Who Received a Stem Cell Transplant. JAMA Oncol. 2022. Epub 20220421. doi: 10.1001/jamaoncol.2022.0752. PubMed PMID: 35446353.

Khan QJ, Bivona CR, Martin GA, Zhang J, Liu B, He J, Li KH, Nelson M, Williamson S, Doolittle GC, Sun W, Mudaranthakam DP, Streeter NR, McGuirk JP, Al-Rajabi R, Hoffmann M, Kasi A, Parikh RA, Zhong C, Mitchell L, Pessetto ZY, Pathak H, Arnab G, LaFaver S, Sharma P, Godwin AK. 

Leadership Diversity and Development in the Nation's Cancer Centers. J Natl Cancer Inst. 2022. Epub 20220728. doi: 10.1093/jnci/djac121. PubMed PMID: 35897143.

Lerman C, Hughes-Halbert C, Falcone M, Gosky DM, Jensen RA, Lee KP, Mitchell E, Odunsi K, Pegher JW, Rodriguez E, Sanchez Y, Shaw R, Weiner G, Willman CL. 

Bladder cancer, inflammageing and microbiomes. Nat Rev Urol. 2022. Epub 20220707. doi: 10.1038/s41585-022-00611-3. PubMed PMID: 35798831.

Martin A, Woolbright BL, Umar S, Ingersoll MA, Taylor JA, 3rd. 

Nicot C. circRNAs shed light on cancer diagnosis and treatment. Mol Cancer. 2022;21(1):107. Epub 20220429. doi: 10.1186/s12943-022-01580-2. PubMed PMID: 35488340; PMCID: PMC9052676.

The complete sequence of a human genome. Science. 2022;376(6588):44-53. Epub 20220331. doi: 10.1126/science.abj6987. PubMed PMID: 35357919.

Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze AV, Mikheenko A, Vollger MR, Altemose N, Uralsky L, Gershman A, Aganezov S, Hoyt SJ, Diekhans M, Logsdon GA, Alonge M, Antonarakis SE, Borchers M, Bouffard GG, Brooks SY, Caldas GV, Chen NC, Cheng H, Chin CS, Chow W, de Lima LG, Dishuck PC, Durbin R, Dvorkina T, Fiddes IT, Formenti G, Fulton RS, Fungtammasan A, Garrison E, Grady PGS, Graves-Lindsay TA, Hall IM, Hansen NF, Hartley GA, Haukness M, Howe K, Hunkapiller MW, Jain C, Jain M, Jarvis ED, Kerpedjiev P, Kirsche M, Kolmogorov M, Korlach J, Kremitzki M, Li H, Maduro VV, Marschall T, McCartney AM, McDaniel J, Miller DE, Mullikin JC, Myers EW, Olson ND, Paten B, Peluso P, Pevzner PA, Porubsky D, Potapova T, Rogaev EI, Rosenfeld JA, Salzberg SL, Schneider VA, Sedlazeck FJ, Shafin K, Shew CJ, Shumate A, Sims Y, Smit AFA, Soto DC, Sovic I, Storer JM, Streets A, Sullivan BA, Thibaud-Nissen F, Torrance J, Wagner J, Walenz BP, Wenger A, Wood JMD, Xiao C, Yan SM, Young AC, Zarate S, Surti U, McCoy RC, Dennis MY, Alexandrov IA, Gerton JL, O'Neill RJ, Timp W, Zook JM, Schatz MC, Eichler EE, Miga KH, Phillippy AM. 

Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease. Kidney Int. 2022. Epub 20220624. doi: 10.1016/j.kint.2022.05.028. PubMed PMID: 35760151.

Parnell SC, Raman A, Zhang Y, Daniel EA, Dai Y, Khanna A, Reif GA, Vivian JL, Fields TA, Wallace DP.

Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and during DNA Replication. J Am Chem Soc. 2022. Epub 20220502. doi: 10.1021/jacs.2c00193. PubMed PMID: 35499923.

Ryan BJ, Yang H, Bacurio JHT, Smith MR, Basu AK, Greenberg MM, Freudenthal BD. 

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling. Nat Commun. 2022;13(1):761. Epub 20220209. doi: 10.1038/s41467-021-27864-7. PubMed PMID: 35140201.

Salas LA, Zhang Z, Koestler DC, Butler RA, Hansen HM, Molinaro AM, Wiencke JK, Kelsey KT, Christensen BC.

Artificial Intelligence and Deep Learning for Upper Gastrointestinal Neoplasia. Gastroenterology. 2022;162(4):1056-66. Epub 20211211. doi: 10.1053/j.gastro.2021.11.040. PubMed PMID: 34902362.

Sharma P, Hassan C. 

Barrett Esophagus: A Review. Jama. 2022;328(7):663-71. doi: 10.1001/jama.2022.13298. PubMed PMID: 35972481.

Sharma P. 

Time to optimize de-escalation strategies in triple-negative breast cancer? Clin Cancer Res. 2022. Epub 20220909. doi: 10.1158/1078-0432.Ccr-22-2140. PubMed PMID: 36083131.

Sharma P. 

NCAPG promotes the oncogenesis and progression of non-small cell lung cancer cells through upregulating LGALS1 expression. Mol Cancer. 2022;21(1):55. Epub 20220218. doi: 10.1186/s12943-022-01533-9. PubMed PMID: 35180865; PMCID: PMC8855584.

Sun H, Zhang H, Yan Y, Li Y, Che G, Zhou C, Nicot C, Ma H. 

Structural basis for APE1 processing DNA damage in the nucleosome. Nat Commun. 2022;13(1):5390. Epub 20220914. doi: 10.1038/s41467-022-33057-7. PubMed PMID: 36104361; PMCID: PMC9474862.

Weaver TM, Hoitsma NM, Spencer JJ, Gakhar L, Schnicker NJ, Freudenthal BD. 

Processing oxidatively damaged bases at DNA strand breaks by APE1. Nucleic Acids Res. 2022. Epub 20220826. doi: 10.1093/nar/gkac695. PubMed PMID: 36018803.

Whitaker AM, Stark WJ, Freudenthal BD. 

The RNA-binding protein HuR in human cancer: a friend or foe? Adv Drug Deliv Rev. 2022:114179. Epub 20220303. doi: 10.1016/j.addr.2022.114179. PubMed PMID: 35248670.

Wu X, Xu L. 

ADAMTS13 protease or lack of von Willebrand factor protects irradiation and melanoma-induced thrombotic microangiopathy in zebrafish. J Thromb Haemost. 2022. Epub 20220727. doi: 10.1111/jth.15820. PubMed PMID: 35894519.

Zheng L, Cao L, Zheng XL. 

Northwestern Cancer Prevention Consortium (A Phase II Clinical Trial of the Multitargeted Recombinant Adenovirus 5 (CEA/MUC1/Brachyury) Vaccine (Tri-Ad5) in Lynch syndrome) | $1,396,000
Bansal, Ajay; Khan SA
Funding Source: National Cancer Institute (NCI), Northwestern U.

Rural Engagement in TelemedTeam for Options in Obesity Treatment Solutions (RE-TOOL) | $4,001,310
Befort, Christie A.
Funding Source: NCI

Development of a Tumor-Retentive Immunostimulant as Adjunct Therapy for Solid Tumor Cancers | $395,595 
Forrest, Marcus Liard; Berkland, Cory J.
Funding Source: NCI, KINIMMUNE, INC.

Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment | $3,275,895
Cox, Lisa
Funding Source: NCI

TEAMSPORT to Community TEAMSPORT: Validating and Adapting a Precision Oncology Reflex Testing Team Intervention to Reduce Rural Disparities in Cancer Care Delivery | $1,772,810
Ellie, Shellie D.; Godwin, Andy K.
Funding Source: NCI

Targeting the Progesterone Receptor as a Novel Means to Increase Efficacy of Immune Checkpoint Inhibitors in Hormone Receptor Positive Breast Cancer | $511,176
Hagan, Christy R.; Hartman ZC
Funding Source: NCI

Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging Among Mid-Life Adults | $372,484
Martin, Laura E.
Funding Source: National Institute on Aging

Roles for Adenomatous Polyposis Coli in Colon Injury Prevention and Wound Healing | $1,115,778
Neufeld, Kristi L.
Funding Source: National Institute of Diabetes and Digestive and Kidney Diseases

4th Generation e-cigarettes in African American Smokers: Reducing Harm and Quitting Combustible Cigarettes in Dual Users | $3,214,375
Nollen, Nikki L.
Funding Source: National Institute on Minority Health and Health Disparities

Modulation of Chemokine Signaling to Mitigate Radiation Induced Inflammation | $3,598,920
Saha, Subhrajit; Dipaolo RJ; Perry, Jerry M.
Funding Source: National Institute of Allergy and Infectious Diseases

Decoding the Assembly and Function of Paralogue Specific SIN3A and SIN3B Human Chromatin Remodeling Complexes and Networks | $1,937,500
Washburn, Michael P.
Funding Source: National Institute of General Medical Sciences (NIGMS)

Modulating Gene Expression by RNA-Targeting Chimeras | $1,912,500
Wang, Jingxin
Funding Source: NIGMS

Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - - Administrative Core; Cells, Tissues, Bioanalysis and Biostatistics Core; Alteration and Renovation; Human Energy Balance Core | $4,000,000
Weinman, Steven; Thyfault, John
Funding Source: NIGMS

DDIR/HRD Status Predicts Response to Chemoimmunotherapy in TNBC | $1,913,088

Stecklein SR; Sharma P  

Funding Source: Department of Defense

Progesterone Promotes Mammary Gland Tumorigenesis Through Immunosuppressive Effects on Dendritic Cells | $135,304
Werner, Lauryn R.; Mentor, Hagan, Christy R.
Funding Source: NCI

Using Contingency Management to Promote Adherence to Smoking Cessation Treatment Among Hospitalized Smokers | $859,805
Cruvinel, Erica N.; Mentor: Nollen, Nikki
Funding Source: National Institute on Drug Abuse

Cancer therapy and Immunogenicity of COVID Vaccine (CANINE Trial) / Principal Investigator (PI): Qamar Khan

MyCare App: A Preliminary Evaluation of its Use in Youth with Hematology/Oncology Disorders / PI: Karen Lewing

First-Line Immunotherapy with Checkpoint Inhibitors: Prospective Assessment of Cognitive Function / PI: Jamie Myers

Exploration of Novel Non-Invasive Breast Cancer Biomarkers Through the MIND Model Study: A Feasibility Project / PI: Lauren Nye

Combined Exercise and Game-based Cognitive Training Intervention: Correlative Study of Neurotrophic and Inflammatory Biomarkers for Women with Breast Cancer / PI: Jamie Myers

Using Ex Vivo Tumoroids to Predict Immunotherapy Response in Non-Small Cell Lung Cancer (NSCLC) (TUMORIN) / PI: Jun Zhang

Prospective Evaluation of GErmline Mutations, Cancer outcome and Tissue biomarkers (P.R.O.G.E.C.T.): A Registry for Patients with Triple-Negative Breast Cancer and Germline Mutations / PI: Priyanka Sharma

Itraconazole Repurposing to Reduce Residual Cancer Risk in Patients with High-Risk Barrett’s Esophagus after Ablation / PI: Ajay Bansal

Using Microbiome to Predict Durvalumab Toxicity in Post-CCRT NSCLC Patients (Microdurva) / PI: Jun Zhang

Tumor Bank / PI: Erin Guest

Microbiome in Immunotherapy Naïve NSCLC Patients Receiving PD-1/L1 Blockade (MIP_NSCLC) / PI: Jun Zhang

Effects of the Combined Exercise and Game-based Cognitive Training on Cancer Therapy-Related Cognitive Impairment in Patients with Breast Cancer: Mixed-Methods Study in the United States and Japan / PI: Jamie Myers

CAFs (Combination of Atezolizumab and pirfenidone in Second line and Beyond NSCLC): A Phase I/II study / PI: Chao Huang

Biomarker Discovery in Patients Receiving Chimeric Antigen Receptor T Cell Therapies / PI: Haitham Abdelhakim

A Pilot Study of Targeted Daunorubicin Dosing to Overcome Chemotherapeutic Resistance in Children with Relapsed or Refractory Acute Leukemia / PI: Chandni Dargan

A Randomized Phase II Trial of Hypo-fractionated Intensity-Modulated Radiation Therapy (IMRT) Utilizing 2.5 Gy/Fraction VS. Standard-Fractionated IMRT Concurrent with Carboplatin/Paclitaxel and Followed by Consolidation Durvalumab for Subjects with Stage IIIA/B NSCLC / PI: Krishna Reddy

A Phase I Study to Evaluate the Safety of Umbilical Cord-Derived Ex-vivo Cultured and Expanded Wharton's Jelly Mesenchymal Stem Cells for the Treatment of De Novo High Risk Acute or Steroid Refractory Acute Graft-versus-Host Disease / PI: Joseph McGuirk

Phase I/II Clinical Trial of Regorafenib Plus Durvalumab (MEDI4736) in Patients with Chemo Refractory Advanced Cholangiocarcinoma / PI: Raed Al-Rajabi

Selective Use of Observation After Lumpectomy and Sentinel Lymph Node Biopsy in Her-2 Positive Patients with Pathologic Complete Response to Neoadjuvant Chemotherapy / PI: Shane Stecklein

The Role of Bladder Cancer TAS2R38 Expression on Chemotherapy-Induced Bitter Taste / PI: Elizabeth Wulff-Burchfield

Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome / PI: Sherwin Chan

A Randomized Phase II Trial of Neo-Adjuvant Chemotherapy with Metformin or Placebo for HER2 Positive Operable Breast Cancer (The HERMET Trial) / PI: Qamar Khan

Longitudinal Geriatric Assessment to Optimize Outcomes of Older Patients with Muscle-Invasive Bladder Cancer after Radical Cystectomy: A Pilot Trial / PI: Elizabeth Wulff-Burchfield

Hypofractionated Radiation Therapy for Patients with Breast Cancer Receiving Regional Nodal Irradiation / PI: Shane Stecklein

Phase II Single Blind Randomized Trial Comparing Morbidity and Mortality of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) using Mitomycin-C versus Melphalan for Colorectal Peritoneal Carcinomatosis / PI: Mazin Al-Kasspooles

Niraparib In Pancreatic Cancer After Previous Chemotherapy (NIRA-PANC): A Phase II Trial / PI: Anup Kasi

A Phase II Study of Perioperative mFOLFOX (Fluorouracil Leucovorin and Oxaliplatin) Chemotherapy Plus Pembrolizumab (MK-3475) Combination in Patients with Potentially Resectable Adenocarcinoma of the Gastroesophageal Junction (GEJ) and Stomach (MISP #52216) / PI: Weijing Sun

Heated Intraperitoneal Chemotherapy in Primary Ovarian Cancer Patients / PI: Andrea Jewell

A Window of Opportunity Trial of Intratumoral Injection of Copaxone® in Patients with Percutaneously Accessible Tumors / PI: Joaquina Baranda

Pediatric Sarcoma Exosomes / PI: Glenson Samuel

Breast Tissue Biomarkers Predicting Short Term Risk of Breast Cancer / PI: Carol Fabian

Emerging from the Haze: Feasibility Pilot Comparing Two Telehealth Virtual Delivery Formats of a Multi-Dimensional Psychoeducational Cognitive Rehabilitation Intervention for Cancer Survivors Reporting Impaired Cognitive Function Post-Chemotherapy / PI: Jamie Myers

Increased Sensitivity of Minimal Residual Disease Monitoring using Peripheral Blood in Pediatric Patients with Acute Lymphoblastic Leukemia / PI: Keith August

Emerging from the HazeTM Substudy: Feasibility pilot for use of MindCap, a Mobile Application to Assess Cognitive Function in Cancer Survivors / PI: Jamie Myers

Novel NanoChip to Detect Exosomal Biomakers in Liquid Biopsy of NSCLC Lung Cancer Patients with Metastasis / PI: Fen Wang

A Phase Ib/IIa Trial of CEND1 In Combination with Neoadjuvant FOLFIRINOX-Based Therapies in Pancreatic, Colon And Appendiceal Cancers (CENDIFOX) / PI: Anup Kasi

A Multi-Center Phase II Study of Ipatasertib in Combination with Docetaxel in Metastatic/Advanced NSCLC Patients Who Have Failed or are Intolerant to 1st Line Immunotherapy / PI: Jun Zhang

Neoadjuvant Phase II Study of Pembrolizumab and Carboplatin plus Docetaxel in Triple-Negative Breast Cancer (NeoPACT) / PI: Priyanka Sharma

IV Vitamin C with Chemotherapy for Cisplatin-Ineligible Bladder Cancer Patients: A Forgotten Group / PI: John Taylor

Phase I Trial of Alpelisib Plus Sacituzumab Govitecan in Patients with Metastatic or Locally Recurrent HER2-Negative Breast Cancer / PI: Priyanka Sharma

A Pilot Trial of Atorvastatin in p53-Mutant and p53 Wild-Type Malignancies / PI: Joaquina Baranda

Phase I Study of Ex Vivo Expanded/Activated Gamma Delta T-Cell Infusion Following Haploidentical Hematopoietic Stem Cell Transplantation and Post-Transplant Cyclophosphamide / PI: Joseph McGuirk

A Phase II Single Arm Proof of Concept Safety, Efficacy Multicenter Study of Brentuximab Vedotin as Consolidation Therapy After Autologous Stem Cell Transplant In CD 30 Expressing Peripheral T Cell Lymphomas (BRENTICON-T) / PI: Marc Hoffmann

Efficacy of Point of Service Testing in Metastatic Breast Cancer (E-POST MBC) / PI: Lauren Nye

Splenic Function Post-Childhood Cancer Therapy / PI: Joy Fulbright